bone strontium measure
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- bone strontium measure
Abstract. The strontium content of bone has hitherto been impossible to measure noninvasively. A novel dual-photon absorptiometry (DPA) method was …
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For instance, strontium-90 is used to measure the density of silk and tobacco products. Strontium-90 has medical applications. A recent advance is to use the isotope for the control of pain. People who have cancer of the bone often experience terrible pain. At one time, the only treatment was medication.
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Measurement of bone strontium (Sr) is vital to determining the effectiveness of Sr supplementation, which is commonly used for the treatment of osteoporosis. Previous …
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A previously developed in vivo X-ray fluorescence (IVXRF) I-125 based system was used to measure bone strontium levels non-invasively in an osteoporotic volunteer. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and …
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Strontium has four naturally occurring isotopes: 84 Sr, 86 Sr, 87 Sr, and 88 Sr (Brown and Brown 2011; Pollard et al. 2017).The amounts of 84 Sr, 86 Sr, and 88 Sr in bedrock are constant and stable but 87 Sr is radiogenic and its amount is dependent on the 87 Rb content in the rock and how much of it has decayed into 87 Sr (Brown and Brown …
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plants and animals are variable; and (2) a range of values in human bone and enamel data make it difficult to distinguish some migrants from locals. Analysis of the bones of small animals provides a robust measure of local strontium isotope ratios and a reliable, if con-servative, means for determining confidence limits for distinguishing ...
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strontium-90, which is an important constituent of nuclear fallout.(8) At that time dietary supplementation of stable strontium was reported to inhibit the intestinal absorption of …
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1078 Keywords: strontium, bone, in vivo, x-ray fluorescence, coherent scatter, Monte Carlo (Some figures may appear in colour only in the online journal) 1. Introduction The calibration of in vivo x-ray fluorescence systems (IVXRF) of bone metal quantification are heavily dependant on a coherent normalization procedure as central to …
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An x-ray fluorescence (XRF) system was developed, which is capable of measuring normal bone strontium levels in vivo non-invasively and therefore has the …
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The bone strontium measures are dimensionless values calculated from the strontium Kα peak counts and normalised to the 125 I coherent peak counts. At baseline, the normalised bone strontium measures in the rats were equivalent across the groups with an overall range of 0.14 to 0.28 (Table 3). Over the 8‐week dosing period, there was …
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The study's objectives were 1) to quantify bone strontium accumulation in Sprague Dawley rats administered strontium citrate (N=7) and compare these levels to rats administered strontium ranelate (N=6) and vehicle (N=6) over 8 weeks, and 2) to verify an in vivo X-ray fluorescence spectroscopy (XRF) system for measurement of bone ...
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The bone strontium measures are dimensionless values calculated from the strontium Kα peak counts and normalised to the 125 I coherent peak counts. At baseline, …
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An x-ray fluorescence (XRF) system was developed, which is capable of measuring normal bone strontium levels in vivo non-invasively and therefore has the potential of becoming an important tool to understand bone strontium health effects. This technique, however, has the limitation that it relies on assumptions about bone …
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Radionuclide Basics: Strontium-90. Strontium (chemical symbol Sr) is a silvery metal that rapidly turns yellowish in air. Naturally occurring strontium is not radioactive. The most common man-made radioactive form of strontium is strontium-90 (Sr-90). Strontium-90 is produced commercially through nuclear. fission. for use in …
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Geochemical Analysis. Strontium isotopes (87 Sr/ 86 Sr) can be analyzed in bone samples in order to determine the likely origin of vegetation consumed by the organism in question.This is based on the fact that plants take up strontium isotope from their underlying soils during growth, generating a distinct 87 Sr/ 86 Sr signature within the …
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Strontium-90, a radioactive isotope, is a by-product of nuclear reactors and present in nuclear fallout. It has a half-life of 28 years. It is absorbed by bone tissue instead of calcium and can destroy bone marrow and cause cancer. However, it is also useful as it is one of the best high-energy beta-emitters known.
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Secondary outcome measures included femoral BMD, incidence of new vertebral deformities, and biochemical markers of bone metabolism. Lumbar BMD, adjusted for bone strontium content, increased in a ...
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Studies of the fate of strontium-90 frea fallout have revealed that an important measure of its impact on nan is the ratio of strontium to calcium in the total diet. "The (Sr/Ca) ratio in new bone being formed is one-fourth of that in the average diet because the body selectively discriminates against strontium" (R»f. •). Typical "Sr/Ca ...
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The ability of this IVXRF system to monitor and measure bone strontium levels over time provides a useful diagnostic tool to help gain insight into strontium bone kinetics.
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Strontium-89 and strontium-90 (89 Sr, 90 Sr), cesium-137 ( 137 Cs), and iodine-131 ( 131 I) are probably the most important contaminants. Strontium is adsorbed into bone, cesium mainly into muscle, and iodine only into the thyroid. These radionuclides are measured by scintillation counting of their radioactivity.
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Measurement of strontium in serum, urine, bone, and soft tissues by Zeeman atomic absorption spectrometry ... Detection limits were 1.2 microg/L (serum), 0.3 microg/L (urine), 0.4 microg/g (bone ...
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Any metal with an atomic number higher than that of calcium can be expected to influence bone mineral density. 28 In experiments, strontium in bone correlated with strontium in plasma. 29 In this ...
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The results of this huge study showed a 60% increase in risk of heart attack from strontium ranelate compared to placebo with a relative risk increase ranging from 1.07-2.38. In other words a 7% to 238% increase in risk and a 50% increased risk of deep blood clot formation, in other words venous thrombotic and embolic events.
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Strontium Ranelate (SrR) is used to treat osteoporosis in Australia/Europe but is not FDA approved in the United States (US). Sr is a heavy element and when incorporated in the bone can cause overestimation of BMD. We report an increase in Bone Mineral Density (BMD) in three patients with osteoporosis who took over the counter SrC.
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However, it is challenging to accurately measure dietary strontium intake due to the regional disparity and the limitations of strontium food composition data [2]. ... In the last decade, extensive studies have been conducted on the effects of strontium on bone [5], [6]. However, little is known regarding the biological mechanism of strontium ...
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Volume 74, December 2022, 127077. In vivo quantification of strontium in bone among adults using portable x-ray fluorescence. Xinxin Zhang a b., Ellen M. Wells a., J. …
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In animals kept on a normal calcium and strontium diet, 98.6% of the calcium and 99.1% of the absorbed strontium are deposited in bone, respectively. Under normal conditions, the bone strontium/calcium ratio varies between 1:1000 and 1:2000, which is on the same order as that noted in serum. 25 Little is known about the extracellular, cellular ...
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For the best results, make sure your samples are clean and free from soil, clay particles, calcite and other detritus. Ash samples in a quartz crucible at 850°C for 3 hours and transfer the residues into clean small glass or plastic vials. A larger sample size is required if we need to ash the samples. Samples are digested in 8 M nitric acid ...
به خواندن ادامه دهیدThe drug makes your bones stronger and lowers your chances of getting fractures. Doctors aren't sure exactly how it works, but it seems to help the body make more bone and keep the bone you have ...
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Some of the isotope is also used in thickness gauges for measuring paper, plastic film, fabrics, and paints. Another radioactive isotope, strontium-89 (half life 50 days) is also a β-emitter and offers a …
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Strontium is a metal ion that is broadly found in the bone and its promoting effects in bone renewal has been revealed 29. In present study, we made chitosan/alginate/strontium doped bioglass ...
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Three good reasons not to take strontium. Taking strontium supplements for any period of time is likely to make future bone density tests inaccurate. (Strontium may remain in the bones for as long as 7–10 years after the last dose.)
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Strontium Ranelate Drug. Strontium's beneficial effects in the treatment of osteoporosis were reported way back in 1910 — but strontium products never entered the market back then due to confusion between the normal, stable forms of strontium with its radioactive isotopes. What everyone heard about was radioactive strontium for building …
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An in vivo X-ray fluorescence I-125 system was used to measure bone strontium levels non-invasively in an osteoporotic . We show bone strontium …
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Strontium-90 (Sr-90) contamination in food is a major public health issue. Several radiochemical methods are available for the determination of Sr-90. However, the application of these procedures is not focused on solid foods, but only on liquid (milk, water, etc.) and environmental matrices, and they were not fully validated. The aims of this work …
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Strontium-89 is an effective alternative for the treatment of bone pain in patients with painful skeletal metastases. The drug is only a palliative measure and not a cure for bone pain or cancer. Moreover, it is ineffective in relieving pain originating from soft tissue tumors, unless bone metastases are involved.
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Measurement of bone strontium (Sr) is vital to determining the effectiveness of Sr supplementation, which is commonly used for the treatment of osteoporosis. Previous technology uses radioisotope sources and bulky equipment to measure bone Sr. This study demonstrates the effectiveness of portable X-ray fluorescence (XRF) for bone Sr …
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The goals of these guidelines are to assist nuclear medical practitioners in: 1. Evaluating patients who might be candidates for treatment of metastatic bone pain using beta-emitting radionuclides such as strontium-89 (89 Sr, approved in Europe and the US), samarium-153 (153 Sm) lexidronam (153 Sm-EDTMP, approved in Europe and the US), …
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To our knowledge, this is the first study to acquire in vivo measures of bone strontium content in the rat. Using a non-invasive XRF system, the in vivo measure of Sr Kα normalised to the coherent scatter of 125 I was strongly correlated to bone strontium content measured by ICP/MS from ex vivo samples of the proximal tibia. These results ...
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